SPG11 NM_025137.4(SPG11):c.6892A>G (p.Ile2298Val)

CI-VAR-00063850Explore in graph →p.Ile2298ValNM_025137.4:c.6892A>GClinVar 413990 rs147962000

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
413990	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Hereditary spastic paraplegia 11; Hereditary spastic paraplegia; Amyotrophic lateral sclerosis type 5; Charcot-Marie-Tooth disease axonal type 2X; Hepatocellular carcinoma	germline	8	Jan 24, 2026	clinvar