AP5Z1 NM_014855.3(AP5Z1):c.1573A>C (p.Lys525Gln)

CI-VAR-00060946Explore in graph →p.Lys525GlnNM_014855.3:c.1573A>CClinVar 412233 rs186003800

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
412233	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Hereditary spastic paraplegia 48; Hereditary spastic paraplegia; Retinal dystrophy; Chronic lymphocytic leukemia/small lymphocytic lymphoma	germline	12	Feb 01, 2026	clinvar