SPG7 NM_003119.4(SPG7):c.1450-1_1457del

CI-VAR-00064836Explore in graph →NM_003119.4:c.1450-1_1457delClinVar 411680 rs768823392

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
411680	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Hereditary spastic paraplegia 7; Hereditary spastic paraplegia; Inborn genetic diseases; Spastic paraparesis; Gait ataxia; Cerebral cortical atrophy; Dysarthria; Spastic paraplegia; Seizure; Memory impairment; Distal spinal muscular atrophy; Malignant tumor of esophagus; Melanoma; SPG7-related disorder	germline	37	Feb 18, 2026	clinvar