FLCN NM_144997.7(FLCN):c.748C>A (p.Leu250Met)

CI-VAR-00064364Explore in graph →p.Leu250MetNM_144997.7:c.748C>AClinVar 409379 rs898441209

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
409379	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Birt-Hogg-Dube syndrome; Hereditary cancer-predisposing syndrome; Familial spontaneous pneumothorax; 17p11.2 microduplication syndrome; Colorectal cancer; Nonpapillary renal cell carcinoma	germline	5	Jan 10, 2026	clinvar