Variant · Snv
HLA-B NM_005514.8(HLA-B):c.991A>G (p.Met331Val)
CI-VAR-00389594Explore in graph →p.Met331ValNM_005514.8:c.991A>GClinVar 4083744
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 4083744 | Likely benign | criteria provided, single submitter | 1 | Colorectal cancer; Gastric cancer; Thymoma; Malignant tumor of esophagus; Familial cancer of breast; Thyroid cancer, nonmedullary, 1; Acute myeloid leukemia; Malignant tumor of urinary bladder; Hepatocellular carcinoma; Uterine corpus endometrial carcinoma; Colon adenocarcinoma; Sarcoma; Ovarian serous cystadenocarcinoma; Lung cancer | germline | 2 | Sep 01, 2025 | clinvar |