POLE NM_006231.4(POLE):c.1346C>T (p.Thr449Met)

CI-VAR-00062683Explore in graph →p.Thr449MetNM_006231.4:c.1346C>TClinVar 405790 rs780299012

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
405790	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	Hereditary cancer-predisposing syndrome; Colorectal cancer; Colorectal cancer, susceptibility to, 12	germline	6	Jan 20, 2026	clinvar