HRAS NM_005343.4(HRAS):c.477G>A (p.Leu159=)

CI-VAR-00007977Explore in graph →p.Leu159=NM_005343.4:c.477G>AClinVar 40446 rs140060409

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
40446	Benign	reviewed by expert panel	3	Costello syndrome; RASopathy; Noonan syndrome and Noonan-related syndrome; Hereditary cancer-predisposing syndrome; Cardiovascular phenotype; Acute myeloid leukemia; Uterine corpus endometrial carcinoma	germline	17	Apr 18, 2017	clinvar