DNA2 NM_001080449.3(DNA2):c.1649A>G (p.Asn550Ser)

CI-VAR-00056702Explore in graph →p.Asn550SerNM_001080449.3:c.1649A>GClinVar 385006 rs141731085

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
385006	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Seckel syndrome 8; Mitochondrial DNA deletion syndrome with progressive myopathy; DNA2-related disorder; Thyroid cancer, nonmedullary, 1; Acute myeloid leukemia; Malignant tumor of urinary bladder; Cervical cancer; Uterine corpus endometrial carcinoma; Ovarian serous cystadenocarcinoma; Clear cell carcinoma of kidney; Uterine carcinosarcoma; Familial cancer of breast	germline	6	Jan 28, 2026	clinvar