Variant · Snv
PIGA NM_002641.4(PIGA):c.55C>T (p.Arg19Trp)
CI-VAR-00058407Explore in graph →p.Arg19TrpNM_002641.4:c.55C>TClinVar 380857 rs34422225
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 380857 | Benign | criteria provided, multiple submitters, no conflicts | 2 | Multiple congenital anomalies-hypotonia-seizures syndrome 2; Inborn genetic diseases; Familial pancreatic carcinoma; Colon adenocarcinoma; Acute myeloid leukemia; Malignant tumor of esophagus; Lymphoma; Uterine carcinosarcoma; Uterine corpus endometrial carcinoma; Thymoma; Melanoma; Chronic lymphocytic leukemia/small lymphocytic lymphoma; Nonpapillary renal cell carcinoma; Familial cancer of breast; Ovarian cancer; Uveal melanoma; Malignant lymphoma, large B-cell, diffuse; Colorectal cancer; Cholangiocarcinoma; Hepatocellular carcinoma | germline | 8 | Feb 03, 2026 | clinvar |