C6 NM_000065.5(C6):c.2381+2T>C

CI-VAR-00056451Explore in graph →NM_000065.5:c.2381+2T>CClinVar 379370 rs76202909

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
379370	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	C6 deficiency, subtotal; Complement component 6 deficiency; C6-related disorder; Melanoma; Hepatocellular carcinoma; Lung cancer; Clear cell carcinoma of kidney; Malignant tumor of urinary bladder; C6-related disorders	germline	23	Mar 17, 2026	clinvar