Variant · Snv
PLA2G6 NM_003560.4(PLA2G6):c.209G>A (p.Arg70Gln)
CI-VAR-00055548Explore in graph →p.Arg70GlnNM_003560.4:c.209G>AClinVar 374459 rs11570607
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 374459 | Conflicting classifications of pathogenicity | criteria provided, conflicting classifications | 1 | Spastic ataxia; PLA2G6-associated neurodegeneration; Infantile neuroaxonal dystrophy; Neurodegeneration with brain iron accumulation 2B; Autosomal recessive Parkinson disease 14; Acute myeloid leukemia | germline | 7 | May 29, 2025 | clinvar |