Variant · Indel

BRCA1 NC_000017.11:g.43041662_43046087delinsTG

CI-VAR-00055459Explore in graph →ClinVar 373858

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
373858	Pathogenic	criteria provided, single submitter	1	Breast-ovarian cancer, familial, susceptibility to, 1	germline	1	Oct 02, 2015	clinvar

Nomenclature

Record

Gene: BRCA1
Type: Indel
HGVS g.: NC_000017.11:g.43041662_43046087delinsTG
Assembly: GRCh38
Position: chr17:43041662-43046087
Ref / Alt: GCCCCACCTGTCTGGGATTCAGTGGGTCTGGGAATTTGCATATCTAACAAATTCCTAGGTGATGGTGTTGCCCCCTCACACTCCTATCAGGGGATCATGCTTTGAGAGCCTCTGCACTGAACTGTAAATGTTAAGCTGTCATATCATTTTGAGTCCTTGAAACCATGTCTCCACAGTTCATATTCCCCAGCCACCAGAGTCGGGAGGATCTCTCTCCAGATCTTGATTCCTACCAGTCCCTTAAACAATTGCTTACATTTTCCTGATCCTCCAGACATTCAGGATCAGCCCCTCTACACCTCCCCAATCCCTGCTCTCCATAGGAGCTGTTTCTAGTTTTCCTTAATTTTCTATTTGGCCAGATTCGTTGCTTTAATTTTCTCCTTGTTACAGGCAGAGTTACAGGCTGTTCAAGAAAACCAGGCATCACTGTAGTGGAAGGGGTTGCCGGCTCAGCCATTTTCCAGTAGTCTTTGATAAGTGAGCCCCCACATTCCCTGGGCAGCAGGCCCCATTCTCTAGGGCTTCTTTGCATAAATCTGCAGCTCCCCCTCATCCTGCCATTCTGTGTGTGCCATCTGCCTCTGGGGCTGACCTTATCTGCTCCTCGCAGCCTTCAGAGGACACCTTCTGGGCAGTTTGGCTCCTTCTGCTCCAACCACCCCAACATTGATTCCTTTCTTTTTCTCCTGCATATTTTTGAGGTGATACTTTGTTGATGATTCTGGTTGCATTTTTTAAGAGGGACATAATCTGCCAGAGCTCTTCTCTAGGCCCCCTCCCTGTGCCTGCATGATAATCCTTTCTCCTCCTTCCTTTCCAGCTTCTTTGTAGAAGTTTGTTTTGTAAAATGAGATAAAGGCAGTACAGGAACTAGTTCCCAATTGCTGCTGTGCCCAGAGAGGGCTAGAGATTGCGGGGTGGAAAAGTGGGAGGACATCTTAAAGTCAGAGGTCAAAGCAACGTGTATTAACTCCATCATCAGGTAGCACTCTTAACCTGGGCCAGGCACCATGAGGCCAGGGCCTGAACTTGACTTCTGGGAAAGGTTATGCAGAGCTTGAAACAGATGGGGTATATGTTTGTTGGGAGACCTTAGAGACAATTACAGAAAACTTTAATGTATTTTAGTCATCTTTGCTTTTACTCACTATTCCTGAAAAGGCAGGCTGTACTAGATGGATACTGCTTTTCCTATTAACCCATTAGTGATGGGGTCAGAAGGCTGAGGCCTGGCTTACCCTCAAGGCCCAGTAGCACTTCTGCTTGCTTCCCGCCTGCCTTTACTACTAACACCGAGACTCATCAACTCACTGGCAGGTAGACAGGGAGCTGGCATGGGCCCTTGGGAAGTCAAGCTGTAGGTGAGGATGAACTGGAAGGCTTTGACAACTAAGATACACAGTCATAAGCTGGGAAGCCAGAGAGAAGTGGAAACAGCAGCCATGATCCACTCCTGTAAGACCCTTTGCCTGACATGGGGCTGCTTTTACTGTCTCCTACTGTGGCCCAAAAGGGAAGTGAGTGTGAGTTCCCCTCAAAATCTAGTTCTCTCTCCAAATTCCCTTAAGGCTTGAACCTTCTGTCCCGGGGTCAGTGACAGAGGCAGATGGAAAGCTGATGATGGGAACAGAAAGGTGGCTTTGGGTCTCCATGTAGTCATTTTTAGCTGTGCAAATCTGAGTAAAATCTTACAAACAAGGAACTTGAGATTCAACTCCCATTTTTCCAATGAGGTAACAAATACCCACTTCATAGGGCTATGATGAAGACTGATATAAAATGTAATATTGGCAGTTAGCTCCATTTTCTCTATCTTCCTTCACTGTTTCCAGCAAATACAGCAGGACTGAACTATGTGATGACTTCATTCTCTTTGCTCAAAAAGGATTCCAATCTCTGAGCAGTGTGAGGACCAGGAAATAATGGTAGAGAGTGTCATCTGTGGATTAAGCATGTTAAATACAAGTGGTAGGCAGAATTCTAAAGATGTCCTCCCTTGATTGCTGTCTTCTGGTTATTCATTCCAACAGTAATCTAGGTACTGCTGCGAAGGGACTTTGCAGCTATAATTAAGGCTATGGGCCTTAAGATATGAAGATCACTTTGGATTACCAAGTGGGTGCAATCTAATCACTTGAGCCCTTAGAAACAGAGAAATGTCTCTGGCAGGAGTTAGAAAGATACAGTAGTCAGCAAGATTCAGTGTGAGAAAAACTTGACCACCCATTGCTGGTTTTGAAGATGGAGGCAGACAGGCCAGGAGCCTAGGAATGTGGGGAGCCTCAAGAAGCTGAGAATGATGCCCAGCCAACAGCCAGTGGGAAACAGGGATCTTAGTCCTAGAACTGCAAGGACCCAGAGCCTCTAGAAGGGAACACGCCCTGCGAACACCTTTATTTTGGCCTCATGAAACCTGAAACAAAGAAACAGTTGAGCCACCTCAGACTTCTGACCTTGCAACAATTTGTTTTGGCAGCAACAGGAAATACAAAAGGTATTTAAGCTGCCTCAATAAATCCTAGGAGGTAGATACTATCATTACCCCCATTTTACAGAGTGGGAGACTGAAGCACAGTGAAAAGGCTCTGAGAAAGTCGGCTGGCCTAAGTCTCAAGAACAGTCATTCATGGTGGAAGTGTTTGCTACCAAGTTTATTTGCAGTGTTAACAGCACAACATTTACAAAACGTATTTTGTACAATCAAGTCTTCACTGCCCTTGCACACTGGGGGGGCTAGGGAAGACCTAGTCCTTCCAACAGCTATAAACAGTCCTGGATAATGGGTTTATGAAAAACACTTTTTCTTCCTTCAGCAAGCAAAATTATTTATGAAGCTGTATGGTTTCAGCAACAGGGAGCAAAGGAAAAAAATCACCTCAAAGAAAGCAACAGCTTCCTTCCTGGTGGGATCTGTCATTTTATAGATATGAAATATTCATGCCAGAGGTCTTATATTTTAAGAGGAATGGATTATATACCAGAGCTACAACAATAAACATTTTACTTATTACTAATGAGGAATTAGAAGACTGTCTTTGGAAACCGGTTCTTGAAAATCTTCTGCTGTTTTAGAACACATTCTTTAGAAATCTAGCAAATATATCTCAGACTTTTAGAAATCTCTTCTAGTTTCATTTTCCTTTTTTTTTTTTTTTTTTTGAGCCACAGTCTCACTGTCACCCAGGCTGGAGTGCCGTGGTATGATCTTGGCTCACTGCAACCTCCACCTCCCGGGCTGAAGTGATTCTCCTGCCTTAGCCACCTGAGTAGCTGGGATTACAGGTGTCCACCACCATGACCGGCTAATTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTTTCGAACTCCTGACCTCCAGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCAGGTTTCAAGTTTCCTTTTCATTTCTAATACCTGCCTCAGAATTTCCTCCCCAATGTTCCACTCCAACATTTGAGAACTGCCCAAGGACTATTCTGACTTTAAGTCACATAATCGATCCCAAGCACTCTCCTTCCATTGAAGGGTCTGACTCTCTGCCTTTGTGAACACAGGGTTTTAGAGAAGTAAACTTAGGGAAACCAGCTATTCTCTTGAGGCCAAGCCACTCTGTGCTTCCAGCCCTAAGCCAACAACAGCCTGAATAGAAAGAATAGGGCTGATAAATAATGAATCAGCATCTTGCTCAATTGGTGGCGTTTAAATGGTTTTAAAATCTTCTCAGGTGAAAAATTACCATAATTTTGTGCTCATGGCAGATTTCCAAGGGAGACTTCAAGCAGAAAATCTTTAAGGGACCCTTGCATAGCCAGAAGTCCTTTTCAGGCTGATGTACATAAAATATTTAGTAGCCAGGACAGTAGAAGGACTGAAGAGTGAGAGGAGCTCCCAGGGCCTGGAAAGGCCACTTTGTAAGCTCATTCTTGGGGTCCTGTGGCTCTGTACCTGTGGCTGGCTGCAGTCAGTAGTGGCTGTGGGGGATCTGGGGTATCAGGTAGGTGTCCAGCTCCTGGCACTGGTAGAGTGCTACACTGTCCAACACCCACTCTCGGGTCACCACAGGTGCCTCACACATCTGCCCAATTGCTGGAGACAGAGAACACAAGCAGAGATTAGTGTCAATTCATTCTCCTGGACTAGGCTCTAATCAATCGACTCCAGGGTCCTGGTTGTATGAGTTCTTAGGATTAATGAGGTAGAAGCTAATTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCGAGGCTAGAGTGTGATGGCGCAATCTCGGCTCATTCAACCTCCGCCTCCTGGGTTCAAGCAATTCTCCTGTCTCTGCCTCCTGAGTAGCTGGAATTACAGGCACATGCCATCACACCCAGCTA → TG