TGFBR2 NM_003242.6(TGFBR2):c.1119G>A (p.Met373Ile)

CI-VAR-00006955Explore in graph →p.Met373IleNM_003242.6:c.1119G>AClinVar 36859 rs35719192

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
36859	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Loeys-Dietz syndrome; Familial thoracic aortic aneurysm and aortic dissection; Marfan syndrome; Connective tissue disorder; Ehlers-Danlos syndrome; Malignant tumor of esophagus; Loeys-Dietz syndrome 2; Colorectal cancer, hereditary nonpolyposis, type 6	germline	25	Apr 01, 2026	clinvar