Variant · Snv
DCLRE1C NM_001033855.3(DCLRE1C):c.457G>A (p.Gly153Arg)
CI-VAR-00006826Explore in graph →p.Gly153ArgNM_001033855.3:c.457G>AClinVar 35998 rs41297018
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 35998 | Benign | reviewed by expert panel | 3 | Severe combined immunodeficiency due to DCLRE1C deficiency; Histiocytic medullary reticulosis; Uterine corpus endometrial carcinoma; Thymoma; Hepatocellular carcinoma; Clear cell carcinoma of kidney; Uveal melanoma; Colon adenocarcinoma; Sarcoma; Gastric cancer; Ovarian serous cystadenocarcinoma; Thyroid cancer, nonmedullary, 1; Lung cancer; Cervical cancer | germline | 16 | Nov 14, 2023 | clinvar |