Variant · Snv
FRAS1 NM_025074.7(FRAS1):c.979C>T (p.Arg327Trp)
CI-VAR-00051225Explore in graph →p.Arg327TrpNM_025074.7:c.979C>TClinVar 349673 rs61999335
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 349673 | Benign/Likely benign | criteria provided, multiple submitters, no conflicts | 2 | Fraser syndrome 1; Clear cell carcinoma of kidney; Colon adenocarcinoma; Sarcoma; Ovarian serous cystadenocarcinoma; Cervical cancer; Ovarian cancer; Thyroid cancer, nonmedullary, 1; Hepatocellular carcinoma; Uterine carcinosarcoma; Melanoma | germline | 8 | Feb 04, 2026 | clinvar |