Variant · Snv
INSR NM_000208.4(INSR):c.2448G>A (p.Thr816=)
CI-VAR-00054258Explore in graph →p.Thr816=NM_000208.4:c.2448G>AClinVar 330460 rs2229434
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 330460 | Benign | criteria provided, multiple submitters, no conflicts | 2 | Rabson-Mendenhall syndrome; Insulin-resistant diabetes mellitus AND acanthosis nigricans; Leprechaunism syndrome; Uterine corpus endometrial carcinoma; Clear cell carcinoma of kidney; Colorectal cancer; Gastric cancer; Thymoma; Cholangiocarcinoma; Melanoma; Hepatocellular carcinoma; Lung cancer; Cervical cancer | germline | 4 | Jan 19, 2026 | clinvar |