IL12RB1 NM_005535.3(IL12RB1):c.1584G>A (p.Arg528=)

CI-VAR-00053292Explore in graph →p.Arg528=NM_005535.3:c.1584G>AClinVar 328579 rs141968777

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
328579	Benign	criteria provided, multiple submitters, no conflicts	2	Mendelian susceptibility to mycobacterial diseases due to complete IL12RB1 deficiency; IL12RB1-related disorder; Ovarian serous cystadenocarcinoma; Lung cancer; Uveal melanoma; Acute myeloid leukemia; Familial cancer of breast	germline	5	Jun 01, 2026	clinvar