Variant · Snv
PPIB NM_000942.5(PPIB):c.63C>A (p.Ser21=)
CI-VAR-00006816Explore in graph →p.Ser21=NM_000942.5:c.63C>AClinVar 31849 rs4904
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 31849 | Benign | criteria provided, multiple submitters, no conflicts | 2 | Osteogenesis imperfecta type 9; Clear cell carcinoma of kidney; Lymphoma; Thyroid cancer, nonmedullary, 1; Cholangiocarcinoma; Uterine corpus endometrial carcinoma; Thymoma; Melanoma; Malignant tumor of esophagus; Uveal melanoma; Colon adenocarcinoma; Nonpapillary renal cell carcinoma; Adrenocortical carcinoma, hereditary; Colorectal cancer; Sarcoma; Lung cancer | germline | 8 | Feb 04, 2026 | clinvar |