SPG11 NM_025137.4(SPG11):c.833A>G (p.Asn278Ser)

CI-VAR-00053872Explore in graph →p.Asn278SerNM_025137.4:c.833A>GClinVar 316111 rs75309308

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
316111	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Hereditary spastic paraplegia 11; Hereditary spastic paraplegia; Amyotrophic lateral sclerosis type 5; Charcot-Marie-Tooth disease axonal type 2X; SPG11-related disorder; Uterine corpus endometrial carcinoma; Malignant lymphoma, large B-cell, diffuse; Cervical cancer; Familial cancer of breast	germline	14	Feb 04, 2026	clinvar