POLR3A NM_007055.4(POLR3A):c.2617-1G>A

CI-VAR-00006803Explore in graph →NM_007055.4:c.2617-1G>AClinVar 31146 rs181087667

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
31146	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism; Neonatal pseudo-hydrocephalic progeroid syndrome; Leukodystrophy; Acute myeloid leukemia; POLR3A-related disorder	germline	16	Apr 15, 2026	clinvar