Variant · Snv
HACL1 NM_012260.4(HACL1):c.451A>T (p.Ile151Phe)
CI-VAR-00338801Explore in graph →p.Ile151PheNM_012260.4:c.451A>TClinVar 3056898 rs74637339
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-06
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260908-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 3056898 | Benign | no assertion criteria provided | 0 | HACL1-related disorder; Sarcoma; Thymoma; Melanoma; Acute myeloid leukemia; Nonpapillary renal cell carcinoma; Malignant lymphoma, large B-cell, diffuse; Colorectal cancer; Uterine corpus endometrial carcinoma; Colon adenocarcinoma; Germ cell tumor of testis | germline | 2 | Jul 30, 2019 | clinvar |