Variant · Snv
SPTBN2 NM_006946.4(SPTBN2):c.1161C>T (p.Arg387=)
CI-VAR-00052961Explore in graph →p.Arg387=NM_006946.4:c.1161C>TClinVar 305591 rs74909073
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 305591 | Benign/Likely benign | criteria provided, multiple submitters, no conflicts | 2 | Lung cancer; Uterine corpus endometrial carcinoma; Colorectal cancer; Sarcoma; Gastric cancer; Melanoma; Cervical cancer | germline | 6 | Jun 01, 2026 | clinvar |