BRIP1 NM_032043.3(BRIP1):c.1045G>C (p.Ala349Pro)

CI-VAR-00006767Explore in graph →p.Ala349ProNM_032043.3:c.1045G>CClinVar 30535 rs149364097

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
30535	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Fanconi anemia complementation group J; Hereditary cancer-predisposing syndrome; Familial cancer of breast; Diffuse intrinsic pontine glioma; Hereditary breast ovarian cancer syndrome; BRIP1-related disorder; Familial ovarian cancer	germline	17	Jan 28, 2026	clinvar