Variant · Snv
SEMA6B NM_032108.4(SEMA6B):c.1223C>T (p.Ala408Val)
CI-VAR-00339150Explore in graph →p.Ala408ValNM_032108.4:c.1223C>TClinVar 3050277 rs142864702
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 3050277 | Conflicting classifications of pathogenicity | no assertion criteria provided | 0 | SEMA6B-related disorder; Retinal dystrophy; Optic atrophy; Malignant tumor of esophagus; Gastric cancer; Hepatocellular carcinoma; Familial cancer of breast | germline | 3 | Jan 01, 2023 | clinvar |