ARFGEF1 NM_006421.5(ARFGEF1):c.1275A>G (p.Leu425=)

CI-VAR-00338852Explore in graph →p.Leu425=NM_006421.5:c.1275A>GClinVar 3033308 rs144593475

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
3033308	Likely benign	criteria provided, multiple submitters, no conflicts	2	ARFGEF1-related disorder; Developmental delay, impaired speech, and behavioral abnormalities, with or without seizures; Thyroid cancer, nonmedullary, 1; Familial cancer of breast; Cervical cancer	germline	5	Feb 01, 2026	clinvar