POT1 NM_015450.3(POT1):c.1426_1427insGCCGGGCGCGGTGGCTCGCGCCTGTAGTCCCAGCACGTCGGGAGGCCGAGGCGGGAGTATGGCGTGGACACGGGAACCGGANNNNNNNNNNAAAAAAAAAAAAAAAAAAAAAATAGTGTAATTCCTG (p.Val476delinsGlyArgAlaArgTrpLeuAlaProValValProAlaArgArgGluAlaGluAlaGlyValTrpArgGlyHisGlyAsnArgXaaXaaXaaXaaLysLysLysLysLysLysLysTer) — variant · CancerIndex

Variant · Insertion

POT1 NM_015450.3(POT1):c.1426_1427insGCCGGGCGCGGTGGCTCGCGCCTGTAGTCCCAGCACGTCGGGAGGCCGAGGCGGGAGTATGGCGTGGACACGGGAACCGGANNNNNNNNNNAAAAAAAAAAAAAAAAAAAAAATAGTGTAATTCCTG (p.Val476delinsGlyArgAlaArgTrpLeuAlaProValValProAlaArgArgGluAlaGluAlaGlyValTrpArgGlyHisGlyAsnArgXaaXaaXaaXaaLysLysLysLysLysLysLysTer)

CI-VAR-00316390Explore in graph →p.Val476delinsGlyArgAlaArgTrpLeuAlaProValValProAlaArgArgGluAlaGluAlaGlyValTrpArgGlyHisGlyAsnArgXaaXaaXaaXaaLysLysLysLysLysLysLysTerNM_015450.3:c.1426_1427insGCCGGGCGCGGTGGCTCGCGCCTGTAGTCCCAGCACGTCGGGAGGCCGAGGCGGGAGTATGGCGTGGACACGGGAACCGGANNNNNNNNNNAAAAAAAAAAAAAAAAAAAAAATAGTGTAATTCCTGClinVar 2749721 rs2485374557

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
2749721	Pathogenic	criteria provided, single submitter	1	Tumor predisposition syndrome 3	germline	1	Aug 03, 2023	clinvar