Variant · Snv
MAMDC4 NM_206920.3(MAMDC4):c.1280C>T (p.Ser427Leu)
CI-VAR-00306258Explore in graph →p.Ser427LeuNM_206920.3:c.1280C>TClinVar 2659758 rs145077934
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 2659758 | Likely benign | criteria provided, single submitter | 1 | Uveal melanoma; Malignant lymphoma, large B-cell, diffuse; Thyroid cancer, nonmedullary, 1; Acute myeloid leukemia; Sarcoma; Clear cell carcinoma of kidney; Familial pancreatic carcinoma; Melanoma; Hepatocellular carcinoma; Gastric cancer; Lymphoma; Ovarian serous cystadenocarcinoma; Malignant tumor of esophagus; Adrenocortical carcinoma, hereditary; Cervical cancer | germline | 2 | Jul 01, 2022 | clinvar |