PLA2G6 NM_003560.4(PLA2G6):c.2221C>T (p.Arg741Trp)

CI-VAR-00048265Explore in graph →p.Arg741TrpNM_003560.4:c.2221C>TClinVar 265448 rs530348521

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
265448	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Infantile neuroaxonal dystrophy; Neurodegeneration with brain iron accumulation 2B; Autosomal recessive Parkinson disease 14; PLA2G6-associated neurodegeneration; Neurodegeneration with brain iron accumulation; Thyroid cancer, nonmedullary, 1	germline	8	Aug 02, 2025	clinvar