Variant · Snv
CCM2 NM_031443.4(CCM2):c.915G>A (p.Thr305=)
CI-VAR-00047275Explore in graph →p.Thr305=NM_031443.4:c.915G>AClinVar 261975 rs2289367
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 261975 | Benign | criteria provided, multiple submitters, no conflicts | 2 | Cerebral cavernous malformation 2; Hepatocellular carcinoma; Familial cancer of breast; CCM2-related disorder; Uterine carcinosarcoma; Nonpapillary renal cell carcinoma; Chronic lymphocytic leukemia/small lymphocytic lymphoma; Malignant lymphoma, large B-cell, diffuse; Ovarian cancer | germline | 11 | Feb 03, 2026 | clinvar |