IRF6 NM_006147.4(IRF6):c.175-5C>G

CI-VAR-00047035Explore in graph →NM_006147.4:c.175-5C>GClinVar 259923 rs7552506

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
259923	Benign	criteria provided, multiple submitters, no conflicts	2	Van der Woude syndrome 1; Van der Woude syndrome; Popliteal pterygium syndrome; Orofacial cleft 6, susceptibility to; Autosomal dominant popliteal pterygium syndrome; Familial cancer of breast; Hepatocellular carcinoma	germline	8	Feb 04, 2026	clinvar