NLRP3 NM_001243133.2(NLRP3):c.2107C>A (p.Gln703Lys)

CI-VAR-00047042Explore in graph →p.Gln703LysNM_001243133.2:c.2107C>AClinVar 259561 rs35829419

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
259561	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Familial cold autoinflammatory syndrome 1; Chronic infantile neurological, cutaneous and articular syndrome; Familial amyloid nephropathy with urticaria AND deafness; Cryopyrin associated periodic syndrome; Autoinflammatory syndrome; Focal segmental glomerulosclerosis; Colon adenocarcinoma; Thymoma; Colorectal cancer; Melanoma; Acute myeloid leukemia; Hepatocellular carcinoma; Cervical cancer; Uterine corpus endometrial carcinoma; Malignant lymphoma, large B-cell, diffuse	germline	20	Jun 01, 2026	clinvar