Variant · Snv
DCTN1 NM_004082.5(DCTN1):c.1484G>A (p.Arg495Gln)
CI-VAR-00047101Explore in graph →p.Arg495GlnNM_004082.5:c.1484G>AClinVar 259232 rs17721059
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 259232 | Conflicting classifications of pathogenicity | criteria provided, conflicting classifications | 1 | Neuronopathy, distal hereditary motor, type 7B; Perry syndrome; Amyotrophic lateral sclerosis type 1; Amyotrophic lateral sclerosis; Thymoma; Melanoma; Cholangiocarcinoma; Acute myeloid leukemia; Uterine corpus endometrial carcinoma; Gastric cancer; Colorectal cancer; Ovarian serous cystadenocarcinoma; Malignant tumor of esophagus | germline | 13 | Jun 01, 2026 | clinvar |