LRP5 NM_002335.4(LRP5):c.3989C>T (p.Ala1330Val)

CI-VAR-00047413Explore in graph →p.Ala1330ValNM_002335.4:c.3989C>TClinVar 258640 rs3736228

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
258640	Benign	criteria provided, multiple submitters, no conflicts	2	Osteoporosis with pseudoglioma; Osteogenesis imperfecta; Adrenocortical carcinoma, hereditary; Disorder of bone; Uveal melanoma; Uterine carcinosarcoma; Colorectal cancer	germline	13	Feb 04, 2026	clinvar