Variant · Snv
SDHA NM_004168.4(SDHA):c.549C>T (p.Gly183=)
CI-VAR-00046497Explore in graph →p.Gly183=NM_004168.4:c.549C>TClinVar 252909 rs61733344
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 252909 | Conflicting classifications of pathogenicity | criteria provided, conflicting classifications | 1 | Mitochondrial complex II deficiency, nuclear type 1; Pheochromocytoma/paraganglioma syndrome 5; Leigh syndrome; Hereditary pheochromocytoma and paraganglioma; Hereditary cancer-predisposing syndrome; Dilated cardiomyopathy 1GG; Neurodegeneration with ataxia and late-onset optic atrophy; Melanoma; Gastric cancer; Uterine carcinosarcoma; Uterine corpus endometrial carcinoma; Clear cell carcinoma of kidney; Sarcoma; Ovarian serous cystadenocarcinoma | germline | 17 | May 01, 2026 | clinvar |