Variant · Snv
SYCP2 NM_014258.4(SYCP2):c.4368C>T (p.Ser1456=)
CI-VAR-00298843Explore in graph →p.Ser1456=NM_014258.4:c.4368C>TClinVar 2498889 rs151218291
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 2498889 | Likely benign | criteria provided, multiple submitters, no conflicts | 2 | SYCP2-related disorder; Hepatocellular carcinoma; Cervical cancer; Familial cancer of breast; Ovarian serous cystadenocarcinoma; Thyroid cancer, nonmedullary, 1; Uterine carcinosarcoma; Malignant tumor of urinary bladder; Clear cell carcinoma of kidney; Sarcoma; Gastric cancer | germline | 4 | Nov 21, 2024 | clinvar |