POLH NM_006502.3(POLH):c.1222_1225del (p.Thr408fs)

CI-VAR-00295106Explore in graph →p.Thr408fsNM_006502.3:c.1222_1225delClinVar 2431387 rs750991026

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
2431387	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Xeroderma pigmentosum variant type; POLH-related disorder	germline	4	May 22, 2024	clinvar