Variant · Snv
PUM1 NM_001020658.2(PUM1):c.2854A>G (p.Ile952Val)
CI-VAR-00294255Explore in graph →p.Ile952ValNM_001020658.2:c.2854A>GClinVar 2342728 rs146226392
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 2342728 | Benign/Likely benign | criteria provided, multiple submitters, no conflicts | 2 | Inborn genetic diseases; PUM1-related disorder; Clear cell carcinoma of kidney; Thyroid cancer, nonmedullary, 1; Familial cancer of breast; Chronic lymphocytic leukemia/small lymphocytic lymphoma; Malignant lymphoma, large B-cell, diffuse; Melanoma; Malignant tumor of esophagus; Nonpapillary renal cell carcinoma; Cervical cancer | germline | 6 | Apr 01, 2026 | clinvar |