PMS2 NM_000535.6(PMS2):c.2182_2184delinsG (p.Thr728Alafs) — variant · CancerIndex

Variant · Indel

PMS2 NM_000535.6(PMS2):c.2182_2184delinsG (p.Thr728Alafs)

CI-VAR-00039101Explore in graph →p.Thr728AlafsNM_000535.6:c.2182_2184delinsGClinVar 231999 rs1554294508

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
231999	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Hereditary cancer-predisposing syndrome; Hereditary nonpolyposis colorectal neoplasms; Hereditary breast ovarian cancer syndrome; Lynch syndrome 4; Hereditary nonpolyposis colon cancer; Lynch syndrome	germline	8	May 02, 2025	clinvar