Variant · Snv
SDHA NM_004168.4(SDHA):c.822C>T (p.Gly274=)
CI-VAR-00037157Explore in graph →p.Gly274=NM_004168.4:c.822C>TClinVar 224953 rs34771391
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 224953 | Conflicting classifications of pathogenicity | criteria provided, conflicting classifications | 1 | Pheochromocytoma/paraganglioma syndrome 5; Mitochondrial complex II deficiency, nuclear type 1; Leigh syndrome; Hereditary pheochromocytoma and paraganglioma; Hereditary cancer-predisposing syndrome; Neurodegeneration with ataxia and late-onset optic atrophy; Dilated cardiomyopathy 1GG; Lung cancer; Uterine corpus endometrial carcinoma; Thyroid cancer, nonmedullary, 1; Nonpapillary renal cell carcinoma; Clear cell carcinoma of kidney; Thymoma; Hepatocellular carcinoma; Colon adenocarcinoma; Sarcoma; Gastric cancer; Ovarian serous cystadenocarcinoma | germline | 15 | Feb 04, 2026 | clinvar |