POLE NM_006231.4(POLE):c.1337G>A (p.Arg446Gln)

CI-VAR-00035612Explore in graph →p.Arg446GlnNM_006231.4:c.1337G>AClinVar 221066 rs151273553

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
221066	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Colorectal cancer, susceptibility to, 12; Hereditary cancer-predisposing syndrome; Familial colorectal cancer; POLE-related disorder; Colorectal cancer, susceptibility to, 10	germline	17	Jan 31, 2026	clinvar