NOTCH1 NM_017617.5(NOTCH1):c.3294C>T (p.Ser1098=)

CI-VAR-00035249Explore in graph →p.Ser1098=NM_017617.5:c.3294C>TClinVar 220792 rs61751546

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
220792	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Adams-Oliver syndrome 5; Aortic valve disease 1; Connective tissue disorder; Familial thoracic aortic aneurysm and aortic dissection; Ovarian serous cystadenocarcinoma; Melanoma; Malignant tumor of urinary bladder; Nonpapillary renal cell carcinoma; Sarcoma; Familial cancer of breast; Colorectal cancer; Gastric cancer; Cervical cancer	germline	17	Jun 01, 2026	clinvar