CDH1 NM_004360.5(CDH1):c.846G>A (p.Met282Ile)

CI-VAR-00035811Explore in graph →p.Met282IleNM_004360.5:c.846G>AClinVar 219957 rs200932258

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
219957	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Hereditary diffuse gastric adenocarcinoma; Hereditary cancer-predisposing syndrome; Malignant tumor of breast; Familial cancer of breast	germline	10	Apr 13, 2026	clinvar