Variant · Snv
FREM1 NM_001379081.2(FREM1):c.1394G>C (p.Gly465Ala)
CI-VAR-00034697Explore in graph →p.Gly465AlaNM_001379081.2:c.1394G>CClinVar 218939 rs41298151
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 218939 | Conflicting classifications of pathogenicity | criteria provided, conflicting classifications | 1 | Congenital diaphragmatic hernia; Oculotrichoanal syndrome; Uterine corpus endometrial carcinoma; Acute myeloid leukemia; Lung cancer; Familial pancreatic carcinoma; Gastric cancer; Ovarian serous cystadenocarcinoma; Thyroid cancer, nonmedullary, 1 | germline | 7 | Jun 01, 2026 | clinvar |