Variant · Snv
POLR3A NM_007055.4(POLR3A):c.2938A>G (p.Ile980Val)
CI-VAR-00033109Explore in graph →p.Ile980ValNM_007055.4:c.2938A>GClinVar 211930 rs146253630
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 211930 | Benign/Likely benign | criteria provided, multiple submitters, no conflicts | 2 | Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism; Neonatal pseudo-hydrocephalic progeroid syndrome; POLR3A-related disorder; Thyroid cancer, nonmedullary, 1; Hepatocellular carcinoma; Malignant tumor of esophagus; Nonpapillary renal cell carcinoma; Sarcoma; Ovarian serous cystadenocarcinoma; Lung cancer; Colon adenocarcinoma; Gastric cancer; Clear cell carcinoma of kidney; Uveal melanoma | germline | 10 | Jun 01, 2026 | clinvar |