LZTR1 NM_006767.4(LZTR1):c.742G>A (p.Gly248Arg)

CI-VAR-00032310Explore in graph →p.Gly248ArgNM_006767.4:c.742G>AClinVar 209088 rs869320686

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
209088	Likely pathogenic	reviewed by expert panel	3	Noonan syndrome 10; LZTR1-related schwannomatosis; Fetal cystic hygroma; Cardiovascular phenotype; Hereditary cancer-predisposing syndrome; RASopathy; Noonan syndrome 1; LZTR1-related disorder; Noonan syndrome	germline	30	Sep 17, 2024	clinvar