FANCM NM_020937.4(FANCM):c.1491dup (p.Gln498fs)

CI-VAR-00032287Explore in graph →p.Gln498fsNM_020937.4:c.1491dupClinVar 208640 rs797045116

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
208640	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Spermatogenic failure 28; Fanconi anemia; Male infertility with azoospermia or oligozoospermia due to single gene mutation; Premature ovarian failure 15; FANCM-related disorder	germline	8	Dec 24, 2025	clinvar