HSD17B3 NM_000197.2(HSD17B3):c.277+4A>T

CI-VAR-00032281Explore in graph →NM_000197.2:c.277+4A>TClinVar 208587 rs201115371

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
208587	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Testosterone 17-beta-dehydrogenase deficiency; Pseudohermaphroditism; Inborn genetic diseases; HSD17B3-related disorder; Malignant tumor of esophagus; Ovarian cancer; Fetal anomalies with a likely genetic cause	germline	20	Jun 29, 2026	clinvar