CACNA1S NM_000069.3(CACNA1S):c.530C>T (p.Ser177Leu)

CI-VAR-00031918Explore in graph →p.Ser177LeuNM_000069.3:c.530C>TClinVar 199686 rs141204958

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
199686	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Malignant hyperthermia of anesthesia; Hypokalemic periodic paralysis, type 1; Malignant hyperthermia, susceptibility to, 5; Long QT syndrome; Congenital myopathy 18; Thyrotoxic periodic paralysis, susceptibility to, 1	germline	14	Jan 25, 2026	clinvar