Variant · Snv
MET NM_000245.4(MET):c.1263C>T (p.Thr421=)
CI-VAR-00028174Explore in graph →p.Thr421=NM_000245.4:c.1263C>TClinVar 184639 rs45499391
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-06
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260908-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 184639 | Benign/Likely benign | criteria provided, multiple submitters, no conflicts | 2 | Hereditary cancer-predisposing syndrome; Papillary renal cell carcinoma type 1; Renal cell carcinoma; MET-related disorder; Osteofibrous dysplasia; Arthrogryposis, distal, IIa 11; Hepatocellular carcinoma; Autosomal recessive nonsyndromic hearing loss 97 | germline | 8 | Dec 31, 2025 | clinvar |