SDHB NM_003000.3(SDHB):c.418G>T (p.Val140Phe)

CI-VAR-00006517Explore in graph →p.Val140PheNM_003000.3:c.418G>TClinVar 18454 rs267607032

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
18454	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Pheochromocytoma/paraganglioma syndrome 4; Hereditary cancer-predisposing syndrome; Hereditary pheochromocytoma and paraganglioma; Gastrointestinal stromal tumor; Pheochromocytoma; SDHB-related disorder; Mitochondrial complex 2 deficiency, nuclear type 4; Carney-Stratakis syndrome	germline	20	Dec 26, 2025	clinvar